Endocrine Abstracts

Background: The indication of ablation with I131 in low-risk DTC is controversial. The exact dose needed for thyroid remnant ablation is still a matter of debate in low-risk DTC patients. However, low dose has been found to be equally effective as high dose in terms of recurrence rate in recent studies. Taking this into account the current trend is to administer lower doses, although some studies describe a higher rate of retreatment.Aims: 1. To examine ...

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...

Objectives: To describe the prevalence of liver steatosis in a cohort of patients with Cushing’s disease.Methods: Cross-sectional descriptive study. We included 59 patients with Cushing’s disease from our cohort of patients who underwent a Fibroscan to analyze the degree of hepatic steatosis (CAP measured in dB/m) and liver fibrosis (fibrosis measured in kPa). Biochemical algorithms of liver steatosis and fibrosis were assessed.<p class="ab...

Introduction: Patients with primary adrenal insufficiency (PAI) require lifelong corticoids replacement and they are at risk of therapy-related osteoporosis and cardiovascular complications.Objectives: Determine the prevalence of cardiovascular risk factors, osteoporosis, and other toxicities related with corticoids treatment.Material and methods: Retrospective, descriptive study in patients with PAI follow up in our service during...

Introduction: It is known that about 75% of cases of endogenous Cushing síndorme to a pituitary adenoma (HA) ACTH-producing, 15% to ectopic ACTH and 10% is due to adrenal adenoma.Case: The patient was 64 years old, derived from Diabetes Mellitus type 2 of about 16 years of history with an unwieldy+hypertension diagnosed in 2007 with no physical signs compatible with hypercortisolism and incidentally detected a left adrenal adenoma 2 cm. Hormonal blo...

Introduction: The prolactinoma is the most common functioning pituitary tumour. There are few long-term studies on the optimal duration of treatment with dopamine agonists prolactinoma to ensure healing without recurrence after stopping the medication and do not provide a consensus on it or on withdrawal criteria treatment.Objectives: To establish the prevalence of withdrawal of treatment macroprolactinomas and evaluate criteria prolactinoma cure medical...

The clinical significance and potential morbidity of papillary thyroid microcarcinomas (PTMC) is discussed. Particularly the differences between those PTMC identified postoperatively in histological examination (incidentals), and those diagnosed preoperatively (non-incidentals). We retrospectively analysed differences in clinical presentation and course after treatment in these two groups. The study population consisted of 199 patients with PTMC who underwent surgery from 2000...

Thirty-two years old female G2P1A0 seen at our endocrinology clinic 9 years ago complaining of persistent menstrual irregularities associated to elevated prolactin values. MRI done revealed a pituitary microadenoma. However, she refused treatment for microprolactinoma. Four years afterwards, patient return complaining of recurrent episodes of headache. Repeated MRI showed a pituitary macroadenoma, so start on cabergoline treatment.Once more, patient was ...

Case of 33 years old male patient with an unremarkable past medical history, who after a car accident, a cystic nodular right neck mass was incidentally found by MRI of cervical spine. Physical examination revealed a mildly tender right neck mass. He was clinically and biochemically euthyroid. Denied history of neck irradiation. No family history of thyroid disease or thyroid cancer. Excisional biopsy of right neck mass showed metastasic well differentiated papillary carcinoma...

Background: CLDN14 gene encodes a protein involved in regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. C allele of the rs219780 SNP of CLDN14 gene has been associated with high levels of PTH and with low bone mineral density (BMD) in women. Our aim is to study the relationship between rs219780 SNP of CLDN14 and fractures, renal lithiasis and bone mineral density in patients with primary hyperparathyr...